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MES MYCOLOGY CROSSWORD No.1

Name: ………………........................   Cosmos Reg. No.: ……........................…….. Date: …...........................…………….

 

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Aspergillus fumigatus

 

ACROSS

  1. A problem with a molecular typing method is the subjective interpretation of a ________ (8)
  2. Assays that detect galactomannan antigen or DNA in BAL fluid may facilitate ________ diagnosis (7)
  3. Current ________ -based methods for evaluation of BAL fluid may have low sensitivity (7)
  4. Farmer's lung is an incurable, allergic lung disease caused by the inhalation of ________ found in mouldy crops such as hay, straw, corn, silage, grain and tabacco (6)
  5. Mortality rates of this ________ infection range from 30% to 90% in neutropenic patients (6)
  6. Farmer's lung is also referred to, in more general terms, as 'extrinsic ________ alveolitis' or 'hypersensitivty pneumonitis' (8)

 

DOWN

  1. Molecular biology techniques have been applied to patients with invasive aspergillois. One study analysed ________ short term repeats, (STR's) markers specific for Aspergillus fumigatus using the STRAf primers (4)
  2. Improved prognosis for invasive pulmonary aspergillosis requires ________ diagnosis (5)
  3. Sources of increased risk include dirty air conditioning units, ________ heaps and damp or flood-damaged housing (7)
  4. A clear advantage of the STRAf assay over random amplified length polymorphism is its ability to identify mixtures of ________ (7)
  5. Other Aspergillus diagnostic methods, for example ________ biopsy, are not often optimal owing to the fragile condition of the patient (6)
  6. Molecular ________ methods based on STRs yield unambiguous data (6)
  7. Mould spores found in crops come from two types of bacteria: Mycropolyspora ________ and Thermoactinomyces vulgaris as well as Aspergillus spp. (5)

 

 

REFERENCES

  • The Aspergillus website, Fungal Research Trust, www.aspergillus.org.uk
  • Characterization and Comparison of Galactomannan Enzyme Immunoassay and Quantitative Real-Time PCR Assay for Detection of Aspergillus fumigatus in Bronchoalveolar Lavage Fluid from Experimental Invasive Pulmonary Aspergillosis. Andrea Francesconi, Miki Kasai, Ruta Petraitiene, Vidmantas Petraitis, Amy M. Kelaher, Robert Schaufele, William W. Hope, Yvonne R. Shea, John Bacher, and Thomas J. Walsh. J Clin Microbiol. 2006 July; 44(7): 2475–2480
  • Comparison of Two Highly Discriminatory Molecular Fingerprinting Assays for Analysis of Multiple Aspergillus fumigatus Isolates from Patients with Invasive Aspergillosis. Hanneke A. de Valk, Jacques F. G. M. Meis, Ben E. de Pauw, Peter J. Donnelly, and Cornι H. W. Klaassen. Journal of Clinical Microbiology, May 2007, p. 1415-1419, Vol. 45, No. 5
  • About.com: lung disease: farmers lung, www.lungdiseases.about.com/od/farmerslung/a/farmers_lung.htm

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