Cosmos Biomedical's Microbiology Education Series (MES)

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Name :........................………………..   Cosmos  Reg. No. :...............................………….. Date :........................

1              4       5                                     3                     2         2           3                                              6               4                                                                       5                                           6

 

Plasmodium falciparum

ACROSS

1 The most common clinical misdiagnoses for malaria patients are hepatitis and gastroenteritis suggesting the importance of obtaining ______ histories (6)

2 From late December 2006 to early January 2007 _____ cases of Plasmodium falciparum malaria were diagnosed in European travellers to northern Goa (5)

3 When comparing epitope frequency between countries, group 1, which includes ________, had a higher frequency of AHHAHHA (8)

4 Classical diagnosis of malaria has been accomplished by examination of ______ -stained thin and thick blood smears under a microscope (6)

5 False positive microscopy can be due to a _______ sp. being diagnosed as malaria parasites (7)

6 Alternative chemoprophylaxis for malaria prevention might be __________, atovaquone plus proguanil or doxycycline (10)

DOWN

1 When comparing microscopy and the OptiMAL test the fifth discrepant sample may have been due to patient _________ (9)

2 Rapid diagnostic tests may be based on the detection of Plasmodium falciparum _________ -rich protein 2 (9)

3 Acronym of the centre that examined microscopy slides in the featured study of the ability to detect Plasmodium falciparum in human urine and saliva (4)

4 The source of malarial DNA in the study described in 3 down may have been released by _____ cells (5)

5 Initial dot blot experiments aimed at improving rapid diagnostic tests investigated the sensitivity of the four tested monoclonal antibodies against the _____ different strains of Plasmodium falciparum (5)

6 The OptiMAL test detects parasite _______ dehydrogenase (7)

 

 

REFERENCES

• Mharakurw S, Simoloka C, Thuma PE, Shiff CJ, Sullivan DJ: PCR detection of Plasmodium falciparum in human urine and saliva sample. Malar J 2006 Nov 8; 5:103 (www.malariajournal.com/content/5/1/103)
• Lee N, Baker J, Andrews KT, Gatton ML, Bell D, Cheng Q, McCarthy J: Effect of sequence variation in Plasmodium falciparum histidine-rich protein 2 on binding of specific monoclonal antibodies: Implications for rapid diagnostic tests for malaria. J Clin Microbiol Aug 2006; 44: 8 (http://jcm.asm.org/cgi/content/full/44/8/2773)
• Palmer CJ, Bonilla JA, Bruckner DA, Barnett ED, Miller NS, Haseeb MA, Masci JR, Stauffer WM: Multicenter study to evaluate the OptiMAL test for rapid diagnosis of malaria in U.S. hospitals. J Clin Microbiol Nov 2003; 41:11 (http://jcm.asm.org/cgi/content/full/41/11/5178)
• CDR Weekly, Vol. 1, No. 2: 12 January 2007 (www.hpa.org.uk)

 

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